Publications

Please, see below for scientific articles and other material related to Vactech's research & development, projects and pipeline.

• Safety, tolerability and immunogenicity of PRV-101, a multivalent vaccine targeting coxsackie B viruses (CVBs) associated with type 1 diabetes: a double-blind randomised placebo-controlled Phase I trial
  Diabetologia. 2024 February 19
  ... The results indicate that the tested multivalent CVB vaccine is well tolerated and immunogenic, supporting its further clinical development.
• An infectious cause for T1D?
  Nature. 2021 June 17
  … identifies enterovirus B as the only virus in the human virome with a significant association with islet autoimmunity.
• Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study
  Gut. 2019 Nov 19. pii: gutjnl-2019-319809
  … describes association between enterovirus B and Celiac Disease.
• Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort
  BMJ. 2019 Feb 13;364:l231
  … Norwegian birth cohort study showing association between enterovirus infections and Celiac Disease.
• Prospective virome analyses in young children at increased genetic risk for type 1 diabetes
  Nat Med. 2019 Dec;25(12):1865-1872
  … publicationby large international NIH-funded research project showing association between enterovirus B and type 1 diabetes using modern virome sequencing technology.
• Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes
  Diabetologia. 2019 May;62(5):744-753
  … reviewarticle written by international team of scientists describing the rational of enterovirus vaccination in type 1 diabetes.
• Developing a vaccine for type 1 diabetes by targeting coxsackievirus B
  Expert Rev Vaccines. 2018 Dec;17(12):1071-1083
  … expertopinion on the development of vaccine against coxsackievirus B and type 1 diabetes.
• Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes
  Diabetes. 2014 Feb;63(2):446-55
  … describes the association between certain enterovirus serotypes and type 1 diabetes (group B coxsackieviruses).
• Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes
  Diabetes. 2014 Feb;63(2):655-62
  … validation of the association between group B coxsackieviruses and Type 1 Diabetes in different European populations.
• A preclinical study on the efficacy and safety of a new vaccine against Coxsackievirus B1 reveals no risk for accelerated diabetes development in mouse models
  Diabetologia. 2015 Feb;58(2):346-54
  … describes safety and efficacy of a prototype vaccine in mice.
• Developing a vaccine for Type 1 diabetes through targeting enteroviral infections
  Expert Rev Vaccines. 2014 Aug;13(8):989-99
  … describes the scenarios of the development of an enterovirus vaccine for the prevention of Type 1 Diabetes.
• Proportion of T1D cases preventable by enterovirus vaccine
  ... a discussion on the estimated efficacy of the preventive Type 1 Diabetes vaccine.
• Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1
  Diabetologia. 2013 Jan;56(1):185-93
  ... shows the expression of enterovirus protein in the pancreatic islets in two different collections of Type 1 Diabetic and control cases.
• Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes
  Diabetes. 2015 May;64(5):1682-7
  ... shows how enterovirus genome can be detected from pancreatic islets and fresh-frozen whole pancreatic tissue of Type 1 Diabetic patients using PCR and sequencing.
• Coxsackievirus B3 VLPs purified by ion exchange chromatography elicit strong immune responses in mice
  Antiviral Res. 2014 Apr;104:93-101
  … explains how the vaccine produced by Vactech's IMAVAC™ VLP technology elicits strong immune responses in mice.
• Coxsackievirus B4 myocarditis and meningoencephalitis in newborn twins
  Neuropathology. 2014 Oct;34(5):429-37
  ... reports pancreatic damage in twin newborns who died during an acute enterovirus infection.
• Enterovirus infection and type 1 diabetes mellitus: systematic review and meta-analysis of observational molecular studies
  BMJ. 2011 Feb 3;342:d35
  … large meta-analysis of studies published on the association between enterovirus infections and Type 1 Diabetes.
• Diabetes and Viruses
  ISBN: 978-1-4614-4050-5
  … a book including several chapters about virus-induced diabetes (published by Springer).